Mykhailo Hordiiovych Derehus (Ukrainian: Дерегус Михайло Гордійович; born December 5, 1904, Vesele, Kharkovsky Uyezd, Kharkov Governorate, Russian Empire — July 31, 1997, Kyiv, Ukraine) was a Soviet Ukrainian graphic artist, painter and educator. In 1969 he was awarded the Shevchenko National Prize. His work is held in the collection of the Kuindzhi Art Museum, Mariupol, Ukraine.